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Cardiovascular

Wells PE Score

Pre-test probability of pulmonary embolism to guide D-dimer and CT-PA decision.

When to use: Use Wells PE score when pulmonary embolism is in the differential for dyspnoea, pleuritic chest pain, or hypoxia. Combined with the PERC rule (score = 0, age <50, HR <100, O₂ sat ≥95%, no prior DVT/PE, no unilateral leg swelling, no haemoptysis, no recent surgery), low-probability patients can be safely discharged without further testing in low-prevalence settings.
Calculator
Leg swelling, tenderness over deep veins
Alternative diagnoses: pneumonia, heart failure, pleuritis

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Formula
Wells PE = DVT signs(3) + PE #1 diagnosis(3) + HR>100(1.5) + Immobilization/surgery(1.5) + Prior DVT/PE(1.5) + Haemoptysis(1) + Malignancy(1) <2 = Low, 2–6 = Moderate, >6 = High
Key Points for NEET PG
  • Wells PE: <2 = Low, 2–6 = Moderate, >6 = High pre-test probability.
  • Classic ECG in PE: S1Q3T3 pattern (S wave in lead I, Q wave and T wave inversion in lead III) — non-specific but high-yield MCQ.
  • Massive PE: haemodynamic instability — systemic thrombolysis (alteplase) is first-line unless contraindicated.
  • CTPA is the gold standard for PE diagnosis; V/Q scan is preferred in pregnancy and renal impairment.
  • PERC rule: if ALL 8 criteria negative AND pretest probability is low, PE risk is <2% — no D-dimer needed.
References
Wells PS et al. Excluding pulmonary embolism at the bedside without diagnostic imaging · Ann Intern Med (2001)
van Belle A et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography · JAMA (2006)

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